Bruna Alice Gomes de Melo

@article{deMelo2020,

title = {Hyaluronic acid and fibrin from L-PRP form semi-IPNs with tunable properties suitable for use in regenerative medicine},

author = {Bruna Alice Gomes de Melo and Carla Giometti França and José Luis Dávila and Nilza Alzira Batista and Carolina Caliari-Oliveira and Marcos Akira d'Ávila and Ângela Cristina Malheiros Luzo and José Fabio Santos Duarte Lana and Maria Helena Andrade Santana},

doi = {10.1016/j.msec.2019.110547},

issn = {0928-4931},

year  = {2020},

date = {2020-04-00},

journal = {Materials Science and Engineering: C},

volume = {109},

publisher = {Elsevier BV},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Mehrotra2020,

title = {Nonmulberry Silk Based Ink for Fabricating Mechanically Robust Cardiac Patches and Endothelialized Myocardium‐on‐a‐Chip Application},

author = {Shreya Mehrotra and Bruna A. G. de Melo and Minoru Hirano and Wendy Keung and Ronald A. Li and Biman B. Mandal and Su Ryon Shin},

doi = {10.1002/adfm.201907436},

issn = {1616-3028},

year  = {2020},

date = {2020-03-00},

journal = {Adv Funct Materials},

volume = {30},

number = {12},

publisher = {Wiley},

abstract = {AbstractBioprinting holds great promise toward engineering functional cardiac tissue constructs for regenerative medicine and as drug test models. However, it is highly limited by the choice of inks that require maintaining a balance between the structure and functional properties associated with the cardiac tissue. In this regard, a novel and mechanically robust biomaterial‐ink based on nonmulberry silk fibroin protein is developed. The silk‐based ink demonstrates suitable mechanical properties required in terms of elasticity and stiffness (≈40 kPa) for developing clinically relevant cardiac tissue constructs. The ink allows the fabrication of stable anisotropic scaffolds using a dual crosslinking method, which are able to support formation of aligned sarcomeres, high expression of gap junction proteins as connexin‐43, and maintain synchronously beating of cardiomyocytes. The printed constructs are found to be nonimmunogenic in vitro and in vivo. Furthermore, delving into an innovative method for fabricating a vascularized myocardial tissue‐on‐a‐chip, the silk‐based ink is used as supporting hydrogel for encapsulating human induced pluripotent stem cell derived cardiac spheroids (hiPSC‐CSs) and creating perfusable vascularized channels via an embedded bioprinting technique. The ability is confirmed of silk‐based supporting hydrogel toward maturation and viability of hiPSC‐CSs and endothelial cells, and for applications in evaluating drug toxicity.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Jodat2020,

title = {A 3D‐Printed Hybrid Nasal Cartilage with Functional Electronic Olfaction},

author = {Yasamin A. Jodat and Kiavash Kiaee and Daniel Vela Jarquin and Rosakaren Ludivina De la Garza Hernández and Ting Wang and Sudeep Joshi and Zahra Rezaei and Bruna Alice Gomes de Melo and David Ge and Manu S. Mannoor and Su Ryon Shin},

doi = {10.1002/advs.201901878},

issn = {2198-3844},

year  = {2020},

date = {2020-03-00},

journal = {Advanced Science},

volume = {7},

number = {5},

publisher = {Wiley},

abstract = {AbstractAdvances in biomanufacturing techniques have opened the doors to recapitulate human sensory organs such as the nose and ear in vitro with adequate levels of functionality. Such advancements have enabled simultaneous targeting of two challenges in engineered sensory organs, especially the nose: i) mechanically robust reconstruction of the nasal cartilage with high precision and ii) replication of the nose functionality: odor perception. Hybrid nasal organs can be equipped with remarkable capabilities such as augmented olfactory perception. Herein, a proof‐of‐concept for an odor‐perceptive nose‐like hybrid, which is composed of a mechanically robust cartilage‐like construct and a biocompatible biosensing platform, is proposed. Specifically, 3D cartilage‐like tissue constructs are created by multi‐material 3D bioprinting using mechanically tunable chondrocyte‐laden bioinks. In addition, by optimizing the composition of stiff and soft bioinks in macro‐scale printed constructs, the competence of this system in providing improved viability and recapitulation of chondrocyte cell behavior in mechanically robust 3D constructs is demonstrated. Furthermore, the engineered cartilage‐like tissue construct is integrated with an electrochemical biosensing system to bring functional olfactory sensations toward multiple specific airway disease biomarkers, explosives, and toxins under biocompatible conditions. Proposed hybrid constructs can lay the groundwork for functional bionic interfaces and humanoid cyborgs.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}