Publicações

@article{pmid32547479,

title = {Clinical Usefulness of SISCOM-SPM Compared to Visual Analysis to Locate the Epileptogenic Zone},

author = {Carla Oliveira Young and Elba C S C Etchbehere and Edna Marina de Souza and Sergio Querino Brunetto and Allan de Oliveira Santos and Mariana C L Lima and Sebastian Ortiz-De la Rosa and Marina Alvim and Clarissa Lin Yasuda and Celso Darío Ramos and Fernando Cendes and Bárbara Juarez Amorim},

doi = {10.3389/fneur.2020.00467},

issn = {1664-2295},

year  = {2020},

date = {2020-01-01},

urldate = {2020-01-01},

journal = {Front Neurol},

volume = {11},

pages = {467},

abstract = { Subtraction of ictal-interictal SPECT co-registered to MRI (SISCOM) is a quantification tool that can improve the sensitivity and specificity of the epileptogenic zone (EZ) localization. Commercially available image analysis software packages for SISCOM are costly, and Statistical Parametric Mapping (SPM) could be an alternative free software for the definition of the EZ. There are only a few studies that compare SISCOM using SPM (SISCOM-SPM) with visual analysis.  To compare SISCOM-SPM vs. visual analysis for localization of the EZ in patients with pharmacoresistant focal epilepsies.  We evaluated all our patients with focal epilepsies that underwent ictal and interictal SPECT. We defined the reference standard to locate the EZ by pathology and follow-up (in patients submitted to surgery), or seizure semiology, serial EEG, long-term video-EEG, F-FDG PET/CT, and MRI (in patients who were not operated). We compared the location of the EZ by visual analysis of SPECT images and by SISCOM-SPM to the reference standard and classified as , or .  We included 23 patients. Visual analysis was  with the EZ reference standard in only 13 patients (56.5%), while SISCOM-SPM was  in 18 cases (78.3%), providing a 21.8% increase in the location of EZ. However, this difference was not significant due to the small sample size ( = 0.0856).  Our preliminary results demonstrate that, in clinical practice, SISCOM-SPM has the potential to add information that might help localize the EZ compared to visual analysis. SISCOM-SPM has a lower cost than other commercially available SISCOM software packages, which is an advantage for developing countries. Studies with more patients are necessary to confirm our findings.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid31667705,

title = {Accuracy of electromagnetic models to estimate cardiomyocyte membrane polarization},

author = {Hugo F M Milan and Rosana Almada Bassani and Luiz E C Santos and Antonio C G Almeida and José Wilson Magalhães Bassani},

doi = {10.1007/s11517-019-02054-2},

issn = {1741-0444},

year  = {2019},

date = {2019-12-01},

urldate = {2019-12-01},

journal = {Med Biol Eng Comput},

volume = {57},

number = {12},

pages = {2617--2627},

abstract = {External electric fields (E) induce a spatially heterogeneous variation in the membrane potential (ΔV) of cardiomyocytes that, if sufficiently large, results in an action potential and contraction. Insights into the phenomenon of ΔV induction by E have been classically gained with electromagnetic models due to the lack of adequate experimental approaches. However, it is not clear yet how reliable these models are. To assess the accuracy of commonly used models, a reference 3D numerical model for cardiomyocytes (NMReal) was developed, consisting of the cell membrane shell reconstructed from rendered confocal microscopy images of freshly isolated ventricular myocytes. NMReal was used to estimate the E-induced maximum ΔV values (ΔV), which were compared with estimates from seven other electromagnetic models. Accurate ΔV estimates (average error < 2%) were obtained with a less complex 3D model (NM3D) based on the extruded 2D image of the cell longitudinal section. Acceptable ΔV estimates (average error < 5%) were obtained with the prolate spheroid analytical model (PSAM) when the angle of E incidence and the cell major axis was < 30°. In this case, PSAM, a much simpler model requiring only the measurement of the longitudinal and transversal cell dimensions, can be a suitable alternative for ΔV calculation. Graphical abstract (A) Confocal images of the cell were used to reconstruct the realistic geometry of cardiomyocytes (NMReal). (B) NMReal was used to estimate the maximum variation in the transmembrane potential (ΔV) induced by an external electric field (E) applied at different angles with respect to the cell major axis. Plus (anode) and minus (cathode) signs indicate electrode position (E direction is from minus to plus). (C) Relative error (vs. NMReal) of ΔV estimation with simplified electromagnetic models, presented in descending order of accuracy (left-to-right, top-to-bottom). NM2D: 2D numerical model based on the longitudinal cell image; NM3D: numerical model based on the z extrusion of NM2D; EAM, PSAM, and CAM: ellipsoidal, prolate spheroidal, and cylindrical analytical models, respectively; PNM and CNM: parallelepipedal and cylindrical numerical models, respectively.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid31605381,

title = {The human central nervous system transmits common synaptic inputs to distinct motor neuron pools during non-synergistic digit actions},

author = {A Del Vecchio and C M Germer and L A Elias and Q Fu and J Fine and M Santello and D Farina},

doi = {10.1113/JP278623},

issn = {1469-7793},

year  = {2019},

date = {2019-12-01},

urldate = {2019-12-01},

journal = {J Physiol},

volume = {597},

number = {24},

pages = {5935--5948},

abstract = {KEY POINTS: Neural connectivity between distinct motor neuronal modules in the spinal cord is classically studied through electrical stimulation or multi-muscle EMG recordings. We quantified the strength of correlation in the activity of two distinct populations of motor neurons innervating the thenar and first dorsal interosseous muscles during tasks that required the two hand muscles to exert matched or un-matched forces in different directions. We show that when the two hand muscles are concurrently activated, synaptic input to the two motor neuron pools is shared across all frequency bandwidths (representing cortical and spinal input) associated with force control. The observed connectivity indicates that motor neuron pools receive common input even when digit actions do not belong to a common behavioural repertoire.nnABSTRACT: Neural connectivity between distinct motor neuronal modules in the spinal cord is classically studied through electrical stimulation or multi-muscle EMG recordings. Here we quantify the strength of correlation in the activity of two distinct populations of motor neurons innervating the thenar and first dorsal interosseous muscles in humans during voluntary contractions. To remove confounds associated with previous studies, we used a task that required the two hand muscles to exert matched or un-matched forces in different directions. Despite the force production task consisting of uncommon digit force coordination patterns, we found that synaptic input to motor neurons is shared across all frequency bands, reflecting cortical and spinal inputs associated with force control. The coherence between discharge timings of the two pools of motor neurons was significant at the delta (0-5 Hz), alpha (5-15 Hz) and beta (15-35 Hz) bands (P < 0.05). These results suggest that correlated input to motor neurons of two hand muscles can occur even during tasks not belonging to a common behavioural repertoire and despite lack of common innervation. Moreover, we show that the extraction of activity from motor neurons during voluntary force control removes cross-talk associated with global EMG recordings, thus allowing direct in vivo interrogation of spinal motor neuron activity.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {BugHeart: software for online monitoring and quantitation of contractile activity of the insect heart},

author = {Arnaldo Fim Neto and Rosana Almada Bassani and Pedro X de Oliveira and José Wilson Magalhães Bassani},

doi = {https://doi.org/10.1007/s42600-019-00026-x},

year  = {2019},

date = {2019-11-09},

urldate = {2019-11-09},

journal = {Research on Biomedical Engineering },

volume = {35},

pages = {235–240},

abstract = {The insect heart (dorsal vessel, DV) is considered a valuable model for studies on cardiac genetics, development, and physiology. However, as software for monitoring and quantitation of insect cardiac activity is not commercially available, most studies depend on time-consuming, post hoc analysis of video records. In this study, a computer program (BugHeart) was developed for this purpose, and applied to the determination of the octopamine effects on Tenebrio molitor DV.



Methods

The software was developed in Labview 11.0 for online processing of amplified video images of the transilluminated DV, in which systolic variation of the luminal diameter can be monitored over successive contraction cycles by video-tracking the tube inner edge. The possibility of adjustment of light intensity threshold and the introduction of calibration allow online quantitation of the DV luminal diameter and its cyclic variation (contraction amplitude), as well as heart rate (HR) estimation. The program can export video and text files for documentation and further analysis.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid31609880,

title = {Technetium-99m-dimercaptosuccinic acid renal scintigraphy and single photon emission computed tomography/computed tomography in patients with sickle cell disease},

author = {Celso Dario Ramos and Daniel Massaro Onusic and Sergio Querino Brunetto and Bárbara Juarez Amorim and Thiago Ferreira Souza and Sara Teresinha Olalla Saad and Mariana da Cunha Lopes Lima},

doi = {10.1097/MNM.0000000000001086},

issn = {1473-5628},

year  = {2019},

date = {2019-11-01},

journal = {Nucl Med Commun},

volume = {40},

number = {11},

pages = {1158--1165},

abstract = {PURPOSE: Sickle cell disease (SCD) is a common hematologic hereditary disorder characterized by vaso-occlusive episodes affecting multiple organs, and substantially alters renal structure and function. We aimed to evaluate the utility of renal scintigraphy and single photon emission computed tomography/computed tomography (SPECT/CT) with technetium-99m-dimercaptosuccinic acid (Tc-DMSA) in adult patients with SCD and no clinical evidence of renal insufficiency.



MATERIALS AND METHODS: Twenty-six patients (16 female) aged 23-58 years with SCD and no clinical evidence of renal insufficiency were prospectively studied. Planar and SPECT/CT images were, respectively, obtained after 3 and 4 hours of the injection of 110-180 MBq of Tc-DMSA. The relative radiopharmaceutical uptake and renal length were, respectively, determined using SPECT and CT images. Planar and SPECT/CT images were visually analyzed to identify focal areas of Tc-DMSA reduced uptake and anatomical deformities of the kidneys.



RESULTS: Focal areas of reduced Tc-DMSA uptake with an image aspect of renal scars or inflammation were present in 21/26 patients (81%). In 11/21 (52%) of these patients, the cortical lesions were clearly identified only on SPECT images. Prominent renal columns were observed in 17/26 (65%) patients. The left kidney tended to be more affected than the right kidney. Most patients had enlarged kidneys.



CONCLUSION: Tc-DMSA scintigraphy and SPECT/CT identify renal lesions possible related to renal infarcts or infections in most adult patients with SCD and no clinical evidence of renal insufficiency. Prominent renal columns and increased renal size tend to occur in most of these patients.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid31712729,

title = {Proposal for a Quantitative F-FDG PET/CT Metabolic Parameter to Assess the Intensity of Bone Involvement in Multiple Myeloma},

author = {Maria Emília Seren Takahashi and Camila Mosci and Edna Marina de Souza and Sergio Querino Brunetto and Elba Etchebehere and Allan O Santos and Mariana R Camacho and Eliana Miranda and Mariana C L Lima and Bárbara Juarez Amorim and Carmino de Souza and Fernando Vieira Pericole and Irene Lorand-Metze and Celso Dario Ramos},

doi = {10.1038/s41598-019-52740-2},

issn = {2045-2322},

year  = {2019},

date = {2019-11-01},

urldate = {2019-11-01},

journal = {Sci Rep},

volume = {9},

number = {1},

pages = {16429},

abstract = {Many efforts have been made to standardize the interpretation of F-FDG PET/CT in multiple myeloma (MM) with qualitative visual analysis or with quantitative metabolic parameters using various methods for lesion segmentation of PET images. The aim of this study was to propose a quantitative method for bone and bone marrow evaluation of F-FDG PET/CT considering the extent and intensity of bone F-FDG uptake: Intensity of Bone Involvement (IBI). Whole body F-FDG PET/CT of 59 consecutive MM patients were evaluated. Compact bone tissue was segmented in PET images using a global threshold for HU of the registered CT image. A whole skeleton mask was created and the percentage of its volume with F-FDG uptake above hepatic uptake was calculated (Percentage of Bone Involvement - PBI). IBI was defined by multiplying PBI by mean SUV above hepatic uptake. IBI was compared with visual analysis performed by two experienced nuclear medicine physicians. IBI calculation was feasible in all images (range:0.00-1.35). Visual analysis categorized PET exams into three groups (negative/mild, moderate and marked bone involvement), that had different ranges of IBI (multi comparison analysis, p < 0.0001). There was an inverse correlation between the patients' hemoglobin values and IBI (r = -0.248;p = 0.02). IBI score is an objective measure of bone and bone marrow involvement in MM, allowing the categorization of patients in different degrees of aggressiveness of the bone disease. The next step is to validate IBI in a larger group of patients, before and after treatment and in a multicentre setting.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid31197752,

title = {Sinusoidal vibrotactile stimulation differentially improves force steadiness depending on contraction intensity},

author = {Carina Marconi Germer and Luciana Sobral Moreira and Leonardo Abdala Elias},

doi = {10.1007/s11517-019-01999-8},

issn = {1741-0444},

year  = {2019},

date = {2019-08-01},

urldate = {2019-08-01},

journal = {Med Biol Eng Comput},

volume = {57},

number = {8},

pages = {1813--1822},

abstract = {Studies have reported the benefits of sensory noise in motor performance, but it is not clear if this phenomenon is influenced by muscle contraction intensity. Additionally, most of the studies investigated the role of a stochastic noise on the improvement of motor control and there is no evidence that a sinusoidal vibrotactile stimulation could also enhance motor performance. Eleven participants performed a sensorimotor task while sinusoidal vibrations were applied to the finger skin. The effects of an optimal vibration (OV) on force steadiness were evaluated in different contraction intensities. We assessed the standard deviation (SD) and coefficient of variation (CoV) of force signals. OV significantly decreased force SD irrespective of contraction intensity, but the decrease in force CoV was significantly higher for low-intensity contraction. To the best of our knowledge, our findings are the first evidence that sinusoidal vibrotactile stimulation can enhance force steadiness in a motor task. Also, the significant improvement caused by OV during low-intensity contractions is probably due to the higher sensitivity of the motor system to the synaptic noise. These results add to the current knowledge on the effects of vibrotactile stimulation in motor control and have potential implications for the development of wearable haptic devices. Graphical abstract In this work the effects of a sinusoidal vibrotactile stimulation on force steadiness was investigated. Index finger sensorimotor tasks were performed in three levels of isometric contraction of the FDI muscle: 5, 10 and 15 %MVC. An optimal level of vibration significantly improved force steadiness, but the decrease in force CoV caused by vibration was more pronounced in contractions at 5 %MVC.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid31084419,

title = {High Thyrotropin Is Critical for Cardiac Electrical Remodeling and Arrhythmia Vulnerability in Hypothyroidism},

author = {Julieta Fernandez-Ruocco and Monica Gallego and Ainhoa Rodriguez-de-Yurre and Julian Zayas-Arrabal and Leyre Echeazarra and Amaia Alquiza and Victor Fernández-López and Juan M Rodriguez-Robledo and Oscar Brito and Ygor Schleier and Marisa Sepulveda and Natália Ferreira Oshiyama and Martin Vila-Petroff and Rosana Almada Bassani and Emiliano H Medei and Oscar Casis},

doi = {10.1089/thy.2018.0709},

issn = {1557-9077},

year  = {2019},

date = {2019-07-01},

urldate = {2019-07-01},

journal = {Thyroid},

volume = {29},

number = {7},

pages = {934--945},

abstract = { Hypothyroidism, the most common endocrine disease, induces cardiac electrical remodeling that creates a substrate for ventricular arrhythmias. Recent studies report that high thyrotropin (TSH) levels are related to cardiac electrical abnormalities and increased mortality rates. The aim of the present work was to investigate the direct effects of TSH on the heart and its possible causative role in the increased incidence of arrhythmia in hypothyroidism.  A new rat model of central hypothyroidism (low TSH levels) was created and characterized together with the classical propylthiouracil-induced primary hypothyroidism model (high TSH levels). Electrocardiograms were recorded , and ionic currents were recorded from isolated ventricular myocytes  by the patch-clamp technique. Protein and mRNA were measured by Western blot and quantitative reverse transcription polymerase chain reaction in rat and human cardiac myocytes. Adult human action potentials were simulated  to incorporate the experimentally observed changes.  Both primary and central hypothyroidism models increased the L-type Ca current (I) and decreased the ultra-rapid delayed rectifier K current (I) densities. However, only primary but not central hypothyroidism showed electrocardiographic repolarization abnormalities and increased ventricular arrhythmia incidence during caffeine/dobutamine challenge. These changes were paralleled by a decrease in the density of the transient outward K current (I) in cardiomyocytes from animals with primary but not central hypothyroidism.  treatment with TSH for 24 hours enhanced isoproterenol-induced spontaneous activity in control ventricular cells and diminished I density in cardiomyocytes from control and central but not primary hypothyroidism animals. In human myocytes, TSH decreased the expression of  and , I, and the delayed rectifier K current (I) encoding proteins in a protein kinase A-dependent way. Transposing the changes produced by hypothyroidism and TSH to a computer model of human ventricular action potential resulted in enhanced occurrence of early afterdepolarizations and arrhythmia mostly in primary hypothyroidism, especially under β-adrenergic stimulation.  The results suggest that suppression of repolarizing K currents by TSH underlies most of the electrical remodeling observed in hypothyroidism. This work demonstrates that the activation of the TSH-receptor/protein kinase A pathway in the heart is responsible for the cardiac electrical remodeling and arrhythmia generation seen in hypothyroidism.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Giesbrecht2019,

title = {Detailed Derivation and Experimental Validation of a Method for Obtaining Load Conditions for Salient Pole Synchronous Machine Quadrature Axis Parameters Determination},

author = {Mateus Giesbrecht and Luis Alfredo Esteves Meneses},

doi = {10.1109/tie.2018.2866096},

issn = {1557-9948},

year  = {2019},

date = {2019-07-00},

journal = {IEEE Trans. Ind. Electron.},

volume = {66},

number = {7},

pages = {5049--5056},

publisher = {Institute of Electrical and Electronics Engineers (IEEE)},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid30877555,

title = {Investigation of anisotropic fishing line-based phantom as tool in quality control of diffusion tensor imaging},

author = {Edna Marina de Souza and Eduardo Tavares Costa and Gabriela Castellano},

doi = {10.1007/s12194-019-00507-9},

issn = {1865-0341},

year  = {2019},

date = {2019-06-01},

journal = {Radiol Phys Technol},

volume = {12},

number = {2},

pages = {161--171},

abstract = {This work proposes a low-cost, fishing line-based phantom for quality control of diffusion tensor imaging (DTI). The device was applied to investigate the relationship between DTI indexes (DTIi) and imaging acquisition parameters. A Dyneema fishing line phantom was built with fiber bundles of different thicknesses. DTI acquisitions were performed in a 3T magnetic resonance imaging scanner using an 8-channel and a 32-channel head coil. For each coil, the following acquisition parameters were changed, one at a time: diffusion sensitivity factor (b value), echo time, sensitivity encoding, voxel size, number of signal averages, and number of diffusion gradient directions (NDGD). DTIi including fractional anisotropy, relative anisotropy (RA), linear anisotropy (CL), and planar anisotropy (CP) were calculated for each image; the data were analyzed using the coefficient of variation (CV) and distributions of DTIi values. The 32-channel head coil presented higher CV values for the DTIi RA, CL, and CP when voxel size was changed. Using the phantom, dependences between diffusion-related parameters (b value and NDGD) and DTIi were also observed; the majority of these were for the smaller thickness fiber bundles. The device proved to be useful for the verification of the DTI performance over time.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid30218147,

title = {Sources of Ca for contraction of the heart tube of Tenebrio molitor (Coleoptera: Tenebrionidae)},

author = {Arnaldo Fim Neto and Rosana Almada Bassani and Pedro X de Oliveira and José Wilson Magalhães Bassani},

doi = {10.1007/s00360-018-1183-0},

issn = {1432-136X},

year  = {2018},

date = {2018-11-01},

urldate = {2018-11-01},

journal = {J Comp Physiol B},

volume = {188},

number = {6},

pages = {929--937},

abstract = {Insect and vertebrate hearts share the ability to generate spontaneously their rhythmic electrical activity, which triggers the fluid-propelling mechanical activity. Although insects have been used as models in studies on the impact of genetic alterations on cardiac function, there is surprisingly little information on the generation of the inotropic activity in their hearts. The main goal of this study was to investigate the sources of Ca for contraction in Tenebrio molitor hearts perfused in situ, in which inotropic activity was assessed by the systolic variation of the cardiac luminal diameter. Increasing the pacing rate from 1.0 to 2.5 Hz depressed contraction amplitude and accelerated relaxation. To avoid inotropic interference of variations in spontaneous rate, which have been shown to occur in insect heart during maneuvers that affect Ca cycling, experiments were performed under electrical pacing at near-physiological rates. Raising the extracellular Ca concentration from 0.5 to 8 mM increased contraction amplitude in a manner sensitive to L-type Ca channel blockade by D600. Inotropic depression was observed after treatment with caffeine or thapsigargin, which impair Ca accumulation by the sarcoplasmic reticulum (SR). D600, but not inhibition of the sarcolemmal Na/Ca exchanger by KB-R7943, further depressed inotropic activity in thapsigargin-treated hearts. From these results, it is possible to conclude that in T. molitor heart, as in vertebrates: (a) inotropic and lusitropic activities are modulated by the heart rate; and (b) Ca availability for contraction depends on both Ca influx via L-type channels and Ca release from the SR.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid28782261,

title = {Minimally invasive measurement of vesical pressure for diagnosis of infravesical obstruction},

author = {João C M de Almeida and Carlos A L D'Ancona and José Wilson Magalhães Bassani},

doi = {10.1002/nau.23366},

issn = {1520-6777},

year  = {2018},

date = {2018-02-01},

urldate = {2018-02-01},

journal = {Neurourol Urodyn},

volume = {37},

number = {2},

pages = {849--853},

abstract = {AIMS: This study was focused on the clinical test of an improved and portable version of a previously described urethral connector (UC), designed for minimally invasive measurement of vesical pressure and diagnosis of infravesical obstruction in men.



METHODS: The conventional pressure-flow study (PFS) and the test with the new version of UC were applied to individuals reporting lower urinary tract symptoms (LUTS), who were then classified as obstructed or non-obstructed/equivocal based on the bladder outlet obstruction index (BOOI) from PFS data. Two-way analysis of variance was used to compare the values of urine flow rate and vesical pressure between methods and diagnoses.



RESULTS: Vesical pressure and urine flow values were not significantly different between methods (P > 0.05), while the former was greater in the group classified as obstructed.



CONCLUSION: The present results showed that the UC test can support the diagnosis of infravesical obstruction in a comparable way as that of the conventional urodynamic method, however with the advantages of simplicity and minimal invasiveness, having thus the potential to be an alternative method for long term follow-up of individuals reporting LUTS.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Phantoms for diffusion-weighted imaging and diffusion tensor imaging quality control: a review and new perspectives},

author = {Edna Marina de Souza and Eduardo Tavares Costa and Gabriela Castellano},

doi = {https://doi.org/10.1590/2446-4740.07816},

year  = {2017},

date = {2017-06-01},

journal = {Res. Biomed. Eng},

volume = {33},

issue = {2},

abstract = {Diffusion-weighted imaging (DWI) and diffusion tensor imaging (DTI) combine magnetic resonance imaging (MRI) techniques and diffusion measures. In DWI, the contrast is defined by microscopic motion of water protons. Nowadays, DWI has become important for early diagnostic of acute stroke. DTI images are calculated from DWI images acquired in at least six directions, which give information of diffusion directionality, making it possible to reconstruct axonal or muscle fiber images. Both techniques have been applied to study body structures in healthy and pathological conditions. Currently, it is known that these images and derived parameters are quite sensitive to factors related to acquisition and processing. Magnetic field inhomogeneity, susceptibility, chemical shift, radiofrequency (RF) interference, eddy currents and low signal-to-noise ratio (SNR) can have a more harmful effect in diffusion data than in T1- or T2-weighted image data. However, even today there are not reference phantoms and guidelines for DWI or DTI quality control (QC).},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Giesbrecht2017,

title = {Finite length white noise generation with an immuno inspired algorithm},

author = {Mateus Giesbrecht and Celso Pascoli Bottura},

doi = {10.1016/j.eswa.2016.10.023},

issn = {0957-4174},

year  = {2017},

date = {2017-03-00},

journal = {Expert Systems with Applications},

volume = {69},

pages = {189--200},

publisher = {Elsevier BV},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {ADHC and Cerebellar Vermian Tumor: sensory and perceptual development through anthroposophic medicine and neuroimaging diagnosis},

author = {Edna Marina de Souza and Maurício Martins Baldissin},

year  = {2017},

date = {2017-01-01},

urldate = {2017-01-01},

journal = {Der Merkurstab},

volume = {1},

number = {59},

keywords = {},

pubstate = {published},

tppubtype = {article}

}